(2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide

C80H71F15N12O14S2 — CID 161496265

About (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide

(2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide (PubChem CID 161496265) has the molecular formula C80H71F15N12O14S2 and a molecular weight of 1773.62 g/mol. Its IUPAC name is (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide.

Molecular Properties

• Compound Name: (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide
• PubChem CID: 161496265
• Molecular Formula: C80H71F15N12O14S2
• Molecular Weight: 1773.62 g/mol
• Exact Mass: 1772.44
• IUPAC Name: (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide
• SMILES: COC[C@@H]1CCc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O1.COC[C@H]1CCc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O1.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](CF)CC2.NC(=O)c1cc(-c2cnc(C(F)F)s2)c2c(n1)O[C@@H](COC(F)F)CC2.NC(=O)c1cc(-c2cnc(C(F)F)s2)c2c(n1)O[C@H](COC(F)F)CC2
• InChI: InChI=1S/2C17H16F2N2O3.C16H13F3N2O2.2C15H13F4N3O3S/c2*1-23-8-10-3-5-12-13(11-4-2-9(18)6-14(11)19)7-15(16(20)22)21-17(12)24-10;17-7-9-2-4-11-12(10-3-1-8(18)5-13(10)19)6-14(15(20)22)21-16(11)23-9;2*16-11(17)14-21-4-10(26-14)8-3-9(12(20)23)22-13-7(8)2-1-6(25-13)5-24-15(18)19/h2*2,4,6-7,10H,3,5,8H2,1H3,(H2,20,22);1,3,5-6,9H,2,4,7H2,(H2,20,22);2*3-4,6,11,15H,1-2,5H2,(H2,20,23)/t2*10-;9-;2*6-/m10010/s1
• InChIKey: WGGBRKIXOJPIHU-ZUHVLJLLSA-N
• XLogP: 14.07
• TPSA: 388.75 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 23
• Rotatable Bonds: 23
• Heavy Atoms: 123
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	1773.62
LogP ≤ 5	14.07
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	23

Frequently Asked Questions

What is the IUPAC name of (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The IUPAC name of (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide (CID 161496265) is (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide.

What is the SMILES notation for (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The canonical SMILES for (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide is COC[C@@H]1CCc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O1.COC[C@H]1CCc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O1.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](CF)CC2.NC(=O)c1cc(-c2cnc(C(F)F)s2)c2c(n1)O[C@@H](COC(F)F)CC2.NC(=O)c1cc(-c2cnc(C(F)F)s2)c2c(n1)O[C@H](COC(F)F)CC2.

What is the InChIKey of (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The InChIKey is WGGBRKIXOJPIHU-ZUHVLJLLSA-N. The full InChI is InChI=1S/2C17H16F2N2O3.C16H13F3N2O2.2C15H13F4N3O3S/c2*1-23-8-10-3-5-12-13(11-4-2-9(18)6-14(11)19)7-15(16(20)22)21-17(12)24-10;17-7-9-2-4-11-12(10-3-1-8(18)5-13(10)19)6-14(15(20)22)21-16(11)23-9;2*16-11(17)14-21-4-10(26-14)8-3-9(12(20)23)22-13-7(8)2-1-6(25-13)5-24-15(18)19/h2*2,4,6-7,10H,3,5,8H2,1H3,(H2,20,22);1,3,5-6,9H,2,4,7H2,(H2,20,22);2*3-4,6,11,15H,1-2,5H2,(H2,20,23)/t2*10-;9-;2*6-/m10010/s1.

What are the key properties of (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

(2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide has a molecular weight of 1773.62 g/mol, XLogP of 14.07, 23 rotatable bonds, 5 hydrogen bond donors, and 23 hydrogen bond acceptors.

Where does this data come from?

All data for (2S)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethoxymethyl)-5-[2-(difluoromethyl)-1,3-thiazol-5-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(fluoromethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-5-(2,4-difluorophenyl)-2-(methoxymethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide is sourced from PubChem (CID 161496265), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).