3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one

C188H228F11N43O13S — CID 162160933

IUPAC3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(C#N)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(OC(F)(F)F)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-n3cc(C4CC4)nn3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CC(F)(F)C3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCC3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2.CNC1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2
InChIInChI=1S/C26H32F3N5O2.C25H30F3N5O2.C25H30N8O.C23H28F2N6O.C23H30N6O.C22H25F3N4O2.C22H25N5O.C22H28N4O3S/c1-32(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-34(23(35)31-24)20-16-21(26(27,28)29)22(30-17-20)33-12-14-36-15-13-33;1-29-24(18-5-3-2-4-6-18)9-7-23(8-10-24)17-33(22(34)31-23)19-15-20(25(26,27)28)21(30-16-19)32-11-13-35-14-12-32;1-31(2)25(19-6-4-3-5-7-19)12-10-24(11-13-25)17-32(23(34)28-24)20-14-26-22(27-15-20)33-16-21(29-30-33)18-8-9-18;1-29(2)22(17-6-4-3-5-7-17)10-8-21(9-11-22)14-31(20(32)28-21)18-12-26-19(27-13-18)30-15-23(24,25)16-30;1-27(2)23(18-7-4-3-5-8-18)11-9-22(10-12-23)17-29(21(30)26-22)19-15-24-20(25-16-19)28-13-6-14-28;1-28(2)21(16-6-4-3-5-7-16)12-10-20(11-13-21)15-29(19(30)27-20)18-9-8-17(14-26-18)31-22(23,24)25;1-26(2)22(18-6-4-3-5-7-18)12-10-21(11-13-22)16-27(20(28)25-21)19-9-8-17(14-23)15-24-19;1-25(2)22(17-7-5-4-6-8-17)13-11-21(12-14-22)16-26(20(27)24-21)19-10-9-18(15-23-19)30(3,28)29/h3-7,16-17H,8-15,18H2,1-2H3,(H,31,35);2-6,15-16,29H,7-14,17H2,1H3,(H,31,34);3-7,14-16,18H,8-13,17H2,1-2H3,(H,28,34);3-7,12-13H,8-11,14-16H2,1-2H3,(H,28,32);3-5,7-8,15-16H,6,9-14,17H2,1-2H3,(H,26,30);3-9,14H,10-13,15H2,1-2H3,(H,27,30);3-9,15H,10-13,16H2,1-2H3,(H,25,28);4-10,15H,11-14,16H2,1-3H3,(H,24,27)
InChIKeyZMLWQGFJXZDWIX-UHFFFAOYSA-N
MW3539.22 g/mol
LogP27.90
Rot. Bonds32

About 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one

3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one (PubChem CID 162160933) has the molecular formula C188H228F11N43O13S and a molecular weight of 3539.22 g/mol. Its IUPAC name is 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one.

Molecular Properties

Compound Name3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
PubChem CID162160933
Molecular FormulaC188H228F11N43O13S
Molecular Weight3539.22 g/mol
Exact Mass3536.80
IUPAC Name3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(C#N)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(OC(F)(F)F)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-n3cc(C4CC4)nn3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CC(F)(F)C3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCC3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2.CNC1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2
InChIInChI=1S/C26H32F3N5O2.C25H30F3N5O2.C25H30N8O.C23H28F2N6O.C23H30N6O.C22H25F3N4O2.C22H25N5O.C22H28N4O3S/c1-32(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-34(23(35)31-24)20-16-21(26(27,28)29)22(30-17-20)33-12-14-36-15-13-33;1-29-24(18-5-3-2-4-6-18)9-7-23(8-10-24)17-33(22(34)31-23)19-15-20(25(26,27)28)21(30-16-19)32-11-13-35-14-12-32;1-31(2)25(19-6-4-3-5-7-19)12-10-24(11-13-25)17-32(23(34)28-24)20-14-26-22(27-15-20)33-16-21(29-30-33)18-8-9-18;1-29(2)22(17-6-4-3-5-7-17)10-8-21(9-11-22)14-31(20(32)28-21)18-12-26-19(27-13-18)30-15-23(24,25)16-30;1-27(2)23(18-7-4-3-5-8-18)11-9-22(10-12-23)17-29(21(30)26-22)19-15-24-20(25-16-19)28-13-6-14-28;1-28(2)21(16-6-4-3-5-7-16)12-10-20(11-13-21)15-29(19(30)27-20)18-9-8-17(14-26-18)31-22(23,24)25;1-26(2)22(18-6-4-3-5-7-18)12-10-21(11-13-22)16-27(20(28)25-21)19-9-8-17(14-23)15-24-19;1-25(2)22(17-7-5-4-6-8-17)13-11-21(12-14-22)16-26(20(27)24-21)19-10-9-18(15-23-19)30(3,28)29/h3-7,16-17H,8-15,18H2,1-2H3,(H,31,35);2-6,15-16,29H,7-14,17H2,1H3,(H,31,34);3-7,14-16,18H,8-13,17H2,1-2H3,(H,28,34);3-7,12-13H,8-11,14-16H2,1-2H3,(H,28,32);3-5,7-8,15-16H,6,9-14,17H2,1-2H3,(H,26,30);3-9,14H,10-13,15H2,1-2H3,(H,27,30);3-9,15H,10-13,16H2,1-2H3,(H,25,28);4-10,15H,11-14,16H2,1-3H3,(H,24,27)
InChIKeyZMLWQGFJXZDWIX-UHFFFAOYSA-N
XLogP27.90
TPSA564.51 Ų
H-Bond Donors9
H-Bond Acceptors40
Rotatable Bonds32
Heavy Atoms256
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003539.22
LogP ≤ 527.90
H-Bond Donors ≤ 59
H-Bond Acceptors ≤ 1040

Analyze 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one with MolForge

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Related Compounds

8-(Dimethylamino)-3-(6-methoxy-4-methyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-methoxy-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-methyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one
CID 158131395
CID 158283197
CID 158283197
CID 158484426
CID 158484426
1-(Cyclopropylmethyl)-8-(methylamino)-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-fluorophenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-fluorophenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;4-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]benzonitrile;8-(dimethylamino)-8-phenyl-3-(2-phenylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-pyridazin-3-yl-1,3-diazaspiro[4.5]decan-2-one;3-methoxy-4-[8-(methylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]benzonitrile;8-(methylamino)-1-(oxetan-3-ylmethyl)-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 158496082
CID 159159662
CID 159159662
CID 159544331
CID 159544331
3-[2-(4-Cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-2-(3-oxopiperazin-1-yl)pyrimidin-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-2-carboxamide;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
CID 161281657
1-(Cyclopropylmethyl)-8-(methylamino)-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-fluorophenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-fluorophenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;4-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]benzonitrile;8-(dimethylamino)-8-phenyl-3-(2-phenylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-pyridazin-3-yl-1,3-diazaspiro[4.5]decan-2-one;3-methoxy-4-[8-(methylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]benzonitrile;8-(methylamino)-1-(oxetan-3-ylmethyl)-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 161599692
8-Amino-1-[(1-hydroxycyclobutyl)methyl]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-fluorophenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-8-phenyl-3-pyrimidin-5-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(3-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonylphenyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-pyridazin-3-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-pyrimidin-5-yl-1,3-diazaspiro[4.5]decan-2-one;3-methoxy-4-[8-(methylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]benzonitrile
CID 161906690
CID 162120141
CID 162120141

Frequently Asked Questions

What is the IUPAC name of 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one?
The IUPAC name of 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one (CID 162160933) is 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one.
What is the SMILES notation for 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one?
The canonical SMILES for 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one is CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(C#N)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(OC(F)(F)F)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-n3cc(C4CC4)nn3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CC(F)(F)C3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCC3)nc1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2.CNC1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(C(F)(F)F)c1)C(=O)N2.
What is the InChIKey of 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one?
The InChIKey is ZMLWQGFJXZDWIX-UHFFFAOYSA-N. The full InChI is InChI=1S/C26H32F3N5O2.C25H30F3N5O2.C25H30N8O.C23H28F2N6O.C23H30N6O.C22H25F3N4O2.C22H25N5O.C22H28N4O3S/c1-32(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-34(23(35)31-24)20-16-21(26(27,28)29)22(30-17-20)33-12-14-36-15-13-33;1-29-24(18-5-3-2-4-6-18)9-7-23(8-10-24)17-33(22(34)31-23)19-15-20(25(26,27)28)21(30-16-19)32-11-13-35-14-12-32;1-31(2)25(19-6-4-3-5-7-19)12-10-24(11-13-25)17-32(23(34)28-24)20-14-26-22(27-15-20)33-16-21(29-30-33)18-8-9-18;1-29(2)22(17-6-4-3-5-7-17)10-8-21(9-11-22)14-31(20(32)28-21)18-12-26-19(27-13-18)30-15-23(24,25)16-30;1-27(2)23(18-7-4-3-5-8-18)11-9-22(10-12-23)17-29(21(30)26-22)19-15-24-20(25-16-19)28-13-6-14-28;1-28(2)21(16-6-4-3-5-7-16)12-10-20(11-13-21)15-29(19(30)27-20)18-9-8-17(14-26-18)31-22(23,24)25;1-26(2)22(18-6-4-3-5-7-18)12-10-21(11-13-22)16-27(20(28)25-21)19-9-8-17(14-23)15-24-19;1-25(2)22(17-7-5-4-6-8-17)13-11-21(12-14-22)16-26(20(27)24-21)19-10-9-18(15-23-19)30(3,28)29/h3-7,16-17H,8-15,18H2,1-2H3,(H,31,35);2-6,15-16,29H,7-14,17H2,1H3,(H,31,34);3-7,14-16,18H,8-13,17H2,1-2H3,(H,28,34);3-7,12-13H,8-11,14-16H2,1-2H3,(H,28,32);3-5,7-8,15-16H,6,9-14,17H2,1-2H3,(H,26,30);3-9,14H,10-13,15H2,1-2H3,(H,27,30);3-9,15H,10-13,16H2,1-2H3,(H,25,28);4-10,15H,11-14,16H2,1-3H3,(H,24,27).
What are the key properties of 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one?
3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one has a molecular weight of 3539.22 g/mol, XLogP of 27.90, 32 rotatable bonds, 9 hydrogen bond donors, and 40 hydrogen bond acceptors.
Where does this data come from?
All data for 3-[2-(azetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(4-cyclopropyltriazol-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[2-(3,3-difluoroazetidin-1-yl)pyrimidin-5-yl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;6-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyridine-3-carbonitrile;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethoxy)-2-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;8-(methylamino)-3-[6-morpholin-4-yl-5-(trifluoromethyl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one is sourced from PubChem (CID 162160933), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).