5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine

C80H63F16N13O3 — CID 165018209

About 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine

5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine (PubChem CID 165018209) has the molecular formula C80H63F16N13O3 and a molecular weight of 1558.44 g/mol. Its IUPAC name is 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine.

Molecular Properties

• Compound Name: 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine
• PubChem CID: 165018209
• Molecular Formula: C80H63F16N13O3
• Molecular Weight: 1558.44 g/mol
• Exact Mass: 1557.49
• IUPAC Name: 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine
• SMILES: CC(C)(Oc1ncc(-c2ccn3nccc3c2)cc1F)C(F)(F)F.Cc1cnn2ccc(-c3cnc(O[C@@H](C)C(F)(F)F)c(F)c3)cc12.Cc1cnn2ccc(-c3cnc(O[C@H](C)C(F)(F)F)c(F)c3)cc12.FC1(F)C[C@@H]1c1ccc(-c2ccn3nccc3c2)cc1.FC1(F)C[C@H]1c1ccc(-c2ccn3nccc3c2)cc1
• InChI: InChI=1S/3C16H13F4N3O.2C16H12F2N2/c1-15(2,16(18,19)20)24-14-13(17)8-11(9-21-14)10-4-6-23-12(7-10)3-5-22-23;2*1-9-7-22-23-4-3-11(6-14(9)23)12-5-13(17)15(21-8-12)24-10(2)16(18,19)20;2*17-16(18)10-15(16)12-3-1-11(2-4-12)13-6-8-20-14(9-13)5-7-19-20/h3-9H,1-2H3;2*3-8,10H,1-2H3;2*1-9,15H,10H2/t;2*10-;2*15-/m.1010/s1
• InChIKey: KTJOPHUMMIJYSD-LXXAFXJUSA-N
• XLogP: 20.85
• TPSA: 152.86 Ų
• H-Bond Acceptors: 16
• Rotatable Bonds: 13
• Heavy Atoms: 112
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	1558.44
LogP ≤ 5	20.85
H-Bond Donors ≤ 5	0
H-Bond Acceptors ≤ 10	16

Frequently Asked Questions

What is the IUPAC name of 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine?

The IUPAC name of 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine (CID 165018209) is 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine.

What is the SMILES notation for 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine?

The canonical SMILES for 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine is CC(C)(Oc1ncc(-c2ccn3nccc3c2)cc1F)C(F)(F)F.Cc1cnn2ccc(-c3cnc(O[C@@H](C)C(F)(F)F)c(F)c3)cc12.Cc1cnn2ccc(-c3cnc(O[C@H](C)C(F)(F)F)c(F)c3)cc12.FC1(F)C[C@@H]1c1ccc(-c2ccn3nccc3c2)cc1.FC1(F)C[C@H]1c1ccc(-c2ccn3nccc3c2)cc1.

What is the InChIKey of 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine?

The InChIKey is KTJOPHUMMIJYSD-LXXAFXJUSA-N. The full InChI is InChI=1S/3C16H13F4N3O.2C16H12F2N2/c1-15(2,16(18,19)20)24-14-13(17)8-11(9-21-14)10-4-6-23-12(7-10)3-5-22-23;2*1-9-7-22-23-4-3-11(6-14(9)23)12-5-13(17)15(21-8-12)24-10(2)16(18,19)20;2*17-16(18)10-15(16)12-3-1-11(2-4-12)13-6-8-20-14(9-13)5-7-19-20/h3-9H,1-2H3;2*3-8,10H,1-2H3;2*1-9,15H,10H2/t;2*10-;2*15-/m.1010/s1.

What are the key properties of 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine?

5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine has a molecular weight of 1558.44 g/mol, XLogP of 20.85, 13 rotatable bonds, 0 hydrogen bond donors, and 16 hydrogen bond acceptors.

Where does this data come from?

All data for 5-[4-[(1R)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[4-[(1S)-2,2-difluorocyclopropyl]phenyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-(1,1,1-trifluoro-2-methylpropan-2-yl)oxy-3-pyridinyl]pyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2S)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine;5-[5-fluoro-6-[(2R)-1,1,1-trifluoropropan-2-yl]oxy-3-pyridinyl]-3-methylpyrazolo[1,5-a]pyridine is sourced from PubChem (CID 165018209), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).