6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide

C20H18F2N4O2S — CID 71261824

IUPAC6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide
SMILESO=C(Nc1cnsc1N1CCC(O)CC1)c1cccc(-c2c(F)cccc2F)n1
InChIInChI=1S/C20H18F2N4O2S/c21-13-3-1-4-14(22)18(13)15-5-2-6-16(24-15)19(28)25-17-11-23-29-20(17)26-9-7-12(27)8-10-26/h1-6,11-12,27H,7-10H2,(H,25,28)
InChIKeySCJPNSNNLGZGCU-UHFFFAOYSA-N
MW416.45 g/mol
LogP3.70
Rot. Bonds4

About 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide

6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide (PubChem CID 71261824) has the molecular formula C20H18F2N4O2S and a molecular weight of 416.45 g/mol. Its IUPAC name is 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide.

Molecular Properties

Compound Name6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide
PubChem CID71261824
Molecular FormulaC20H18F2N4O2S
Molecular Weight416.45 g/mol
Exact Mass416.11
IUPAC Name6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide
SMILESO=C(Nc1cnsc1N1CCC(O)CC1)c1cccc(-c2c(F)cccc2F)n1
InChIInChI=1S/C20H18F2N4O2S/c21-13-3-1-4-14(22)18(13)15-5-2-6-16(24-15)19(28)25-17-11-23-29-20(17)26-9-7-12(27)8-10-26/h1-6,11-12,27H,7-10H2,(H,25,28)
InChIKeySCJPNSNNLGZGCU-UHFFFAOYSA-N
XLogP3.70
TPSA78.35 Ų
H-Bond Donors2
H-Bond Acceptors6
Rotatable Bonds4
Heavy Atoms29
Complexity—

Lipinski Rule of Five

Passes Rule of Five

RuleValue
MW ≤ 500416.45
LogP ≤ 53.70
H-Bond Donors ≤ 52
H-Bond Acceptors ≤ 106

Analyze 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide with MolForge

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Related Compounds

3-amino-6-(2,6-difluorophenyl)-N-[5-(3-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide
CID 71261836
2-(2,6-difluorophenyl)-N-[5-[4-(1-hydroxyethyl)piperidin-1-yl]-1,2-thiazol-4-yl]-1,3-thiazole-4-carboxamide
CID 71261832
N-[5-(azetidin-3-ylmethoxy)-1,2-thiazol-4-yl]-6-(2,6-difluorophenyl)pyridine-2-carboxamide
CID 118413386
N-[5-(3-azabicyclo[3.2.1]octan-3-yl)-1,2-thiazol-4-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
CID 152845077
6-(2,6-difluorophenyl)-N-(4-piperidin-4-yloxy-3-pyridinyl)pyridine-2-carboxamide
CID 71262676
2-(2,6-difluorophenyl)-N-[5-[3-(hydroxymethyl)morpholin-4-yl]-1,2-thiazol-4-yl]-1,3-thiazole-4-carboxamide
CID 78056493
6-(2,6-difluorophenyl)-5-fluoro-N-(5-piperidin-4-yloxy-1,2-thiazol-4-yl)pyridine-2-carboxamide;hydrochloride
CID 126744026
N-[4-[(3S)-3-aminopyrrolidin-1-yl]-7-fluoro-2-methylindazol-5-yl]-6-(2-fluoro-6-methoxyphenyl)pyridine-2-carboxamide
CID 168988527
3-amino-6-(2,6-difluorophenyl)-N-[5-(piperidin-4-ylmethoxy)-1,2-thiazol-4-yl]pyridine-2-carboxamide
CID 71261907
2-fluoro-N-[2-(4-hydroxypiperidin-1-yl)phenyl]benzamide
CID 110900198
3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-yl-[6-(2,6-difluorophenyl)-2-pyridinyl]methanone
CID 58210834
6-(2,6-difluorophenyl)-5-fluoro-N-[5-(piperidin-3-ylmethoxy)-1,2-thiazol-4-yl]pyridine-2-carboxamide
CID 118413433

Frequently Asked Questions

What is the IUPAC name of 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide?
The IUPAC name of 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide (CID 71261824) is 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide.
What is the SMILES notation for 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide?
The canonical SMILES for 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide is O=C(Nc1cnsc1N1CCC(O)CC1)c1cccc(-c2c(F)cccc2F)n1.
What is the InChIKey of 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide?
The InChIKey is SCJPNSNNLGZGCU-UHFFFAOYSA-N. The full InChI is InChI=1S/C20H18F2N4O2S/c21-13-3-1-4-14(22)18(13)15-5-2-6-16(24-15)19(28)25-17-11-23-29-20(17)26-9-7-12(27)8-10-26/h1-6,11-12,27H,7-10H2,(H,25,28).
What are the key properties of 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide?
6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide has a molecular weight of 416.45 g/mol, XLogP of 3.70, 4 rotatable bonds, 2 hydrogen bond donors, and 6 hydrogen bond acceptors.
Where does this data come from?
All data for 6-(2,6-difluorophenyl)-N-[5-(4-hydroxypiperidin-1-yl)-1,2-thiazol-4-yl]pyridine-2-carboxamide is sourced from PubChem (CID 71261824), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).