Dehydrogenase/reductase SDR family member 12 (DHRS12)

About Dehydrogenase/reductase SDR family member 12

Dehydrogenase/reductase SDR family member 12 (DHRS12) is a protein from Homo sapiens identified by UniProt accession A0PJE2, 317 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Dehydrogenase/reductase SDR family member 12
UniProt accession	A0PJE2
Gene	DHRS12
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
heel bone mineral density · score 0.32
neutrophil count · score 0.29
monocyte count · score 0.28
lysophosphatidylethanolamine measurement · score 0.28
protein measurement · score 0.25
myeloid white cell count · score 0.19
cystatin C measurement · score 0.19
leukocyte count · score 0.16
cognitive decline measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A0PJE2-F1	alphafold	PREDICTED	95.24	—

Amino-acid sequence (317 residues)

MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS GIGKATALEI AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL SDPKQIWKFV ENFKQEHKLH VLINNAGCMV NKRELTEDGL EKNFAANTLG VYILTTGLIP VLEKEHDPRV ITVSSGGMLV QKLNTNDLQS ERTPFDGTMV YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA MPGFHARFGD RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA EEEKLIEILE QLAQTFK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards