About TLD domain-containing protein 2
TLD domain-containing protein 2 (TLDC2) is a protein
from Homo sapiens identified by UniProt accession
A0PJX2, 215 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | TLD domain-containing protein 2 |
|---|
| UniProt accession | A0PJX2 |
|---|
| Gene | TLDC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 215 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- Aicardi-Goutières syndrome · score 0.19
- chilblain lupus · score 0.18
- lean body mass · score 0.15
- Aicardi-Goutieres syndrome · score 0.14
- genetic disorder · score 0.12
- lymphocyte percentage of leukocytes · score 0.11
- fat body mass · score 0.11
- base metabolic rate measurement · score 0.09
- body height · score 0.08
- lymphocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A0PJX2-F1 | alphafold | PREDICTED | 85.77 | — |
Amino-acid sequence (215 residues)
MRGLRWRYTR LPSQVEDTLS GEEGNEEEEE EEAAPDPAAA PEDPTVPQLT EASQVLSASE IRQLSFHFPP RVTGHPWSLV FCTSRDGFSL QSLYRRMEGC SGPVLLVLRD QDGQIFGAFS SSAIRLSKGF YGTGETFLFS FSPQLKVFKW TGSNSFFVKG DLDSLMMGSG SGRFGLWLDG DLFRGGSSPC PTFNNEVLAR QEQFCIQELE AWLLS
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