Fez family zinc finger protein 1 (FEZF1)

About Fez family zinc finger protein 1

Fez family zinc finger protein 1 (FEZF1) is a protein from Homo sapiens identified by UniProt accession A0PJY2, 475 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Fez family zinc finger protein 1
UniProt accession	A0PJY2
Gene	FEZF1
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

Kallmann syndrome · score 0.52
hypogonadotropic hypogonadism · score 0.51
diet measurement · score 0.42
age at first sexual intercourse measurement · score 0.42
chronotype measurement · score 0.30
lean body mass · score 0.19
genetic disorder · score 0.19
fat body mass · score 0.18
body mass index · score 0.17
body height · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A0PJY2-F1	alphafold	PREDICTED	56.00	—

Amino-acid sequence (475 residues)

MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH FLQGALPKGE PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL EAPAAPAAVP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP VASYFLSSPL HPQPKTYLAE RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF TCPTCGKGFC RNFDLKKHVR KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP MTLPPLQPPL PTPGPLQPGL HQGHQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards