About Transmembrane protein 120B
Transmembrane protein 120B (TMEM120B) is a protein
from Homo sapiens identified by UniProt accession
A0PK00, 339 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Transmembrane protein 120B |
|---|
| UniProt accession | A0PK00 |
|---|
| Gene | TMEM120B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 339 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- mean platelet volume · score 0.36
- self reported educational attainment · score 0.31
- mean reticulocyte volume · score 0.30
- mood instability measurement · score 0.29
- mathematical ability · score 0.24
- age at menopause · score 0.24
- platelet crit · score 0.23
- neutrophil count · score 0.22
- reticulocyte count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A0PK00-F1 | alphafold | PREDICTED | 91.66 | — |
Amino-acid sequence (339 residues)
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Explore Transmembrane protein 120B with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets