About Transmembrane protein 72
Transmembrane protein 72 (TMEM72) is a protein
from Homo sapiens identified by UniProt accession
A0PK05, 275 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Transmembrane protein 72 |
|---|
| UniProt accession | A0PK05 |
|---|
| Gene | TMEM72 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.48
- erythrocyte count · score 0.46
- mean corpuscular hemoglobin concentration · score 0.44
- mean corpuscular hemoglobin · score 0.42
- mean reticulocyte volume · score 0.41
- diastolic blood pressure · score 0.40
- red blood cell density measurement · score 0.40
- hypertension · score 0.37
- reticulocyte measurement · score 0.34
- cardiovascular disease · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A0PK05-F1 | alphafold | PREDICTED | 57.44 | — |
Amino-acid sequence (275 residues)
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA AVSICEGAYF VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS VACFLHPVLV WHVTIPGSML IITGLAYFLL SKRKKRKAAP EVLASPEQYT DPSSSAVSTT GSGDTEQTYT FHGALKEGPS SLFIHMKSIL KGTKKPSALQ PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD DGDSEPEETT SDTTPIIPPP QAPLFLSSLT ATGLF
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