About FERM domain-containing protein 3
FERM domain-containing protein 3 (FRMD3) is a protein
from Homo sapiens identified by UniProt accession
A2A2Y4, 597 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | FERM domain-containing protein 3 |
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| UniProt accession | A2A2Y4 |
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| Gene | FRMD3 |
|---|
| Organism | Homo sapiens |
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| Length | 597 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- hypertension · score 0.40
- neurofibrillary tangles measurement · score 0.33
- body height · score 0.32
- diastolic blood pressure · score 0.32
- pulse pressure measurement · score 0.32
- systolic blood pressure · score 0.32
- neuroblastoma · score 0.16
- neoplasm · score 0.09
- breast cancer · score 0.07
- mean corpuscular volume · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2A2Y4-F1 | alphafold | PREDICTED | 74.53 | — |
Amino-acid sequence (597 residues)
MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS
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