About Tetratricopeptide repeat protein 24
Tetratricopeptide repeat protein 24 (TTC24) is a protein
from Homo sapiens identified by UniProt accession
A2A3L6, 582 residues long.
MolForge cross-references it against 0 known binders and
6 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 24 |
|---|
| UniProt accession | A2A3L6 |
|---|
| Gene | TTC24 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 582 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (6)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.08
- protein measurement · score 0.04
- creatine kinase measurement · score 0.02
- cutaneous lupus erythematosus · score 0.01
- Sepsis · score 0.01
- small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2A3L6-F1 | alphafold | PREDICTED | 73.79 | — |
Amino-acid sequence (582 residues)
MSSPNPEDVP RRPEPEPSSS NKKKKKRKWL RQEASIQALT RAGHGALQAG QNHEALNNFQ RAFLLASKAP QTRDTPVLQA CAFNLGAAYV ETGDPARGLE LLLRAHPEEK AQGRRHGDQC FNVALAYHAL GELPQALAWY HRALGHYQPQ GDQGEAWAKM GACYQALGQP ELAAHCLQEA SQAYAQERQL RAAALALGAA AGCMLKSGRH RVGEVVQVLE KSRRLAERST ERRLLGHLYN DLGLGYSQLQ LFPLAVEAFL QALPLCWVPG EQATVLRNLG MAHNALGNYQ EAREFHQKAA DLHGSVGQRW EQGRSFGSLA FALSQLGDHK AARDNYLHAL QAARDSGDMK GQWQACEGLG AAAARLGQYD QALKYYKEAL AQCQKEPDSV RERLVAKLAD TVRTRLAQVG LVQTHTLTSA PGRLQAPGGA SQAEGTPAKA GSSTAGVQHR SSSGWEDEEF EEGHQKKKEE RSANVPVRAG PGRPELCFLP GTVNHSHHLA SSCPTFTKHT PCRGTVLGKA SIYSPGPRAH LPFVGPGPPR AEYPSILVPN GPQANRSSRW PRESLSRSRQ RRPMESGICT IV
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