About Transmembrane protein 89
Transmembrane protein 89 (TMEM89) is a protein
from Homo sapiens identified by UniProt accession
A2RUT3, 159 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Transmembrane protein 89 |
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| UniProt accession | A2RUT3 |
|---|
| Gene | TMEM89 |
|---|
| Organism | Homo sapiens |
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| Length | 159 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (10)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.24
- reticulocyte count · score 0.05
- chronotype measurement · score 0.05
- urolithiasis · score 0.04
- ureterolithiasis · score 0.04
- nephrolithiasis · score 0.04
- Immature Reticulocyte Fraction Measurement · score 0.03
- reticulocyte measurement · score 0.02
- small cell lung carcinoma · score 0.01
- systemic lupus erythematosus · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A2RUT3-F1 | alphafold | PREDICTED | 62.22 | — |
Amino-acid sequence (159 residues)
MLHVLASLPL LLLLVTSAST HAWSRPLWYQ VGLDLQPWGC QPKSVEGCRG GLSCPGYWLG PGASRIYPVA AVMITTTMLM ICRKILQGRR RSQATKGEHP QVTTEPCGPW KRRAPISDHT LLRGVLHMLD ALLVHIEGHL RHLATQRQIQ IKGTSTQSG
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