About Gamma-secretase-activating protein
Gamma-secretase-activating protein (GSAP) is a protein
from Homo sapiens identified by UniProt accession
A4D1B5, 854 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Gamma-secretase-activating protein |
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| UniProt accession | A4D1B5 |
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| Gene | GSAP |
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| Organism | Homo sapiens |
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| Length | 854 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- Eczematoid dermatitis · score 0.43
- allergic rhinitis · score 0.39
- asthma · score 0.39
- body mass index · score 0.35
- adolescent idiopathic scoliosis · score 0.30
- seasonal allergic rhinitis · score 0.30
- allergic disease · score 0.29
- HbA1c measurement · score 0.29
- lymphocyte count · score 0.28
- type 2 diabetes mellitus · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4D1B5-F1 | alphafold | PREDICTED | 80.46 | — |
Amino-acid sequence (854 residues)
MALRLVADFD LGKDVLPWLR AQRAVSEASG AGSGGADVLE NDYESLHVLN VERNGNIIYT YKDDKGNVVF GLYDCQTRQN ELLYTFEKDL QVFSCSVNSE RTLLAASLVQ STKEGKRNEL QPGSKCLTLL VEIHPVNNVK VLKAVDSYIW VQFLYPHIES HPLPENHLLL ISEEKYIEQF RIHVAQEDGN RVVIKNSGHL PRDRIAEDFV WAQWDMSEQR LYYIDLKKSR SILKCIQFYA DESYNLMFEV PLDISLSNSG FKLVNFGCDY HQYRDKFSKH LTLCVFTNHT GSLCVCYSPK CASWGQITYS VFYIHKGHSK TFTTSLENVG SHMTKGITFL NLDYYVAVYL PGHFFHLLNV QHPDLICHNL FLTGNNEMID MLPHCPLQSL SGSLVLDCCS GKLYRALLSQ SSLLQLLQNT CLDCEKMAAL HCALYCGQGA QFLEAQIIQW ISENVSACHS FDLIQEFIIA SSYWSVYSET SNMDKLLPHS SVLTWNTEIP GITLVTEDIA LPLMKVLSFK GYWEKLNSNL EYVKYAKPHF HYNNSVVRRE WHNLISEEKT GKRRSAAYVR NILDNAVKVI SNLEARNLGP RLTPLLQEED SHQRLLMGLM VSELKDHFLR HLQGVEKKKI EQMVLDYISK LLDLICHIVE TNWRKHNLHS WVLHFNSRGS AAEFAVFHIM TRILEATNSL FLPLPPGFHT LHTILGVQCL PLHNLLHCID SGVLLLTETA VIRLMKDLDN TEKNEKLKFS IIVRLPPLIG QKICRLWDHP MSSNIISRNH VTRLLQNYKK QPRNSMINKS SFSVEFLPLN YFIEILTDIE SSNQALYPFE GHDNVDAEFV EEAALKHTAM LLGL
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