About Killer cell lectin-like receptor subfamily G member 2
Killer cell lectin-like receptor subfamily G member 2 (KLRG2) is a protein
from Homo sapiens identified by UniProt accession
A4D1S0, 409 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Killer cell lectin-like receptor subfamily G member 2 |
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| UniProt accession | A4D1S0 |
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| Gene | KLRG2 |
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| Organism | Homo sapiens |
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| Length | 409 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- glycoprotein storage disease · score 0.05
- colorectal adenocarcinoma · score 0.04
- esophageal adenocarcinoma · score 0.04
- hemoglobin H disease · score 0.04
- hemoglobin C-beta-thalassemia syndrome · score 0.04
- combined immunodeficiency due to OX40 deficiency · score 0.04
- dominant beta-thalassemia · score 0.04
- Hyperlipoproteinemia type 1 · score 0.04
- Felty's syndrome · score 0.04
- congenital nonspherocytic hemolytic anemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A4D1S0-F1 | alphafold | PREDICTED | 58.18 | — |
Amino-acid sequence (409 residues)
MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD GDEKLPRAVT LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG AWRGPQGWHW IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR PWVCAKGTQ
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