About Xin actin-binding repeat-containing protein 2
Xin actin-binding repeat-containing protein 2 (XIRP2) is a protein
from Homo sapiens identified by UniProt accession
A4UGR9, 3374 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Xin actin-binding repeat-containing protein 2 |
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| UniProt accession | A4UGR9 |
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| Gene | XIRP2 |
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| Organism | Homo sapiens |
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| Length | 3374 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- body mass index · score 0.31
- protein measurement · score 0.30
- atopic eczema · score 0.21
- metabolite measurement · score 0.16
- DNA methylation · score 0.14
- congenital heart disease · score 0.13
- Blepharophimosis · score 0.11
- hypertrophic cardiomyopathy · score 0.07
- left ventricular noncompaction · score 0.06
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3374 residues)
MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKTES EYEETFKPSS VVSTSSTSCV STSQRKETST TRYSDHSVTS STLAQINATS SGMTEEFPPP PPDVLQTSVD VTAFSQSPEL PSPPRRLPVP KDVYSKQRNL YELNRLYKHI HPELRKNLEK DYISEVSEIV SSQMNSGSSV SADVQQARYV FENTNDSSQK DLNSEREYLE WDEILKGEVQ SIRWIFENQP LDSINNGSPD EGDISRGIAD QEIIAGGDVK YTTWMFETQP IDTLGAYSSD TVENAEKIPE LARGDVCTAR WMFETRPLDS MNKMHQSQEE SAVTISKDIT GGDVKTVRYM FETQHLDQLG QLHSVDEVHL LQLRSELKEI KGNVKRSIKC FETQPLYVIR DGSGQMLEIK TVHREDVEKG DVRTARWMFE TQPLDTINKD ITEIKVVRGI SMEENVKGGV SKAKWLFETQ PLEKIKESEE VIIEKEKIIG TDVSRKCWMF ETQPLDILKE VPDADSLQRE EIIGGDVQTT KHLFETLPIE ALKDSPDIGK LQKITASEEE KGDVRHQKWI FETQPLEDIR KDKKEYTRTV KLEEVDRGDV KNYTHIFESN NLIKFDASHK IEVEGVTRGA VELNKSLFET TPLYAIQDPL GKYHQVKTVQ QEEIVRGDVR SCRWLFETRP IDQFDESIHK FQIIRGISAQ EIQTGNVKSA KWLFETQPLD SIKYFSDVEE TESKTEQTRD IVKGDVKTCK WLFETQPMES LYEKVSLMTS SEEIHKGDVK TCTWLFETQP LDTIKDDSET AVKLQTVKQE EIQGGDVRTA CFLFETENLD SIQGEEVKEI KPVEMDIQAG DVSSMRYKFE NQSLDSISSS SEEVLKKIKT LKTEDIQKGN VLNCRWLFEN QPIDKIKESQ EGDECVKTVT DIQGGDVRKG CFIFETFSLD EIKEESDYIS TKKTITEEVI QGDVKSYRML FETQPLYAIQ DREGSYHEVT TVKKEEVIHG DVRGTRWLFE TKPLDSINKS ETVYVIKSVT QEDIQKGDVS SVRYRFETQP LDQISEESHN IMPSIDHIQG GNVKTSRQFF ESENFDKNNY IRTVSVNEIQ KGNVKTSTWL FETHTMDELR GEGLEYENIK TVTQEDVQKG DVKQAVWLFE NRTFDSIMEA HKGITKMTKE EIPPSDVKTT TWLFETTPLH EFNETRVEKI EIIGKSIKET LEDLYSQKVI QAPGIIIEAD EIGDVRMAKY KLMNQASPEI QKEEIIRADL RNIMVNLLSK RDCTEREILI SEEEKGNVNL TKTQLLNRST EFHAEKEEIV KGDVQQAIKN LFSEERSVKK GILIQEDEKG DINMTIYCLL HENDGDTIER EEVIGGDVKR TIHNLLSSTS NNKISERAKI DASERGNVQF FTTCIEAGAL DYLKQLHTES NETLTAKKQE GEKEIIGGDV EGTKLLLKKR QSLVERTVSE TDIIPGDVHN TVKVFMTEPQ STFGKIPKEE IIKGDLTSTL NSLSQAVNQK TVTKTEEIIK GNMLATLKSL KESSHRWKES KQPDAIPGDI EKAIECLEKA TNTKTEILKK ELLKDDLETS LRSLKEAQRS FKEVHKEGVI KKDAKAVMAG SSGEQKTDIH QVAVQRNKNS LLQPKPGPFE PAAKWQGGAD TLSQTMGKSC HGNLVEERTE VNLPKAPKGT VKIVIDREQN NDALEKSLRR LSNSHHKSNV LESGDKTGVW TDTTGEQHLR DEYMSRQLTS TVSVKNNLTT KESDRAVREL KKDDVFNSIQ SAGKTVGKQQ TYELRNDHQK MEGFHIKSPK KTKNIKILTD TQSSKPSPTQ HPVSMPVGGT YDLSGDFQKQ TLLKQETKYS NKDIKKKNIN LQPMWQLLPV EQDTSNVTEM KVSEKSHNTF KATNKKRETD VHLKSQDFLM KTNTSTGLKM AMERSLNPIN FNPENNVKES ECPLPPPSPP PPPPSNASSE IEFPLPPPPP LMMFPEKNGF LPSLSTEKIK AEFESFPGLP LPPPPVDEKS ERESSSMFLP PPPPPTPSQK PAHLLSSSAP EKHSGDFMQQ YSQKEASNSQ NSQAKIITGK TGVLPPPTLP KPKLPKHIKD NKNDFSPKVE LATSLSDMEC KITTSKDQKK VMVMTSSEHT ETKQNVISKS LDERKQLSID SANCLSHTVP GTSAPRKKQI APLIKSHSFP ESSGQQNPKP YMRKFKTPLM IAEEKYRQQK EEIEKQKQES SYYNIVKTQS QNQHITEVEK EMPLQKTNEE VSLSGIDSEC TVVQPSPGSQ SNARILGVCS DNQLSTTSPE TVAAKRLHHV LAASEDKDKM KKEVLQSSRD IMQSKSACEI KQSHQECSTQ QTQQKKYLEQ LHLPQSKPIS PNFKVKTIKL PTLDHTLNET DHSYESHKQQ SEIDVQTFTK KQYLKTKKTE ASTECSHKQS LAERHYQLPK KEKRVTVQLP TESIQKNQED KLKMVPRKQR EFSGSDRGKL PGSEEKNQGP SMIGRKEERL ITERKHEHLK NKSAPKVVKQ KVIDAHLDSQ TQNFQQTQIQ TAESKAEHKK LPQPYNSLQE EKCLEVKGIQ EKQVFSNTKD SKQEITQNKS FFSSVKESQR DDGKGALNIV EFLRKREELQ QILSRVKQFE AEPNKSGLKT FQTLLNTIPG WLISEDKREY AVHIAMENNL EKVKEEITHI KTQAEDMLVS YENIIQTAMM SSKTGKPGNK PTSLDETSSK VSNVHVSNNK NSEQKENKIA KEKTVQHQVA AHHEATVRSH VKTHQEIKLD DSNIPPPSLK TRPPSPTFIT IESTARRTEN PTKNELSQSP KKDSYVEPPP RRPMSQKSEI HRANTSPSPP RSRSEQLVRL KDTTAKLSKG AIPCPAATPV PIVEKRSEII MSPATLRRQI KIETRGRDSP PTITIPVNIN HAASGSFRES VDAQEEIRKV EKRATYVHKD GLNSTDHMVP DTESYDAVEI IRKVAVPPRL SEHTQRYEAA NRTVQMAENF VNDPENEINR WFREFEHGPV SEAKSNRRVY AKGETNHNIQ QESRTFCKEE FGLTSLGNTS FTDFSCKHPR ELREKIPVKQ PRICSETRSL SEHFSGMDAF ESQIVESKMK TSSSHSSEAG KSGCDFKHAP PTYEDVIAGH ILDISDSPKE VRKNFQKTWQ ESGRVFKGLG YATADASATE MRTTFQEESA FISEAAAPRQ GNMYTLSKDS LSNGVPSGRQ AEFS
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