About Vacuolar protein sorting-associated protein 37C
Vacuolar protein sorting-associated protein 37C (VPS37C) is a protein
from Homo sapiens identified by UniProt accession
A5D8V6, 355 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 37C |
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| UniProt accession | A5D8V6 |
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| Gene | VPS37C |
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| Organism | Homo sapiens |
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| Length | 355 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.53
- viral disease · score 0.46
- neurodegenerative disease · score 0.25
- adolescent idiopathic scoliosis · score 0.14
- eosinophil count · score 0.02
- systolic blood pressure · score 0.02
- smoking status measurement · score 0.02
- ovarian carcinoma · score 0.01
- psoriasis · score 0.01
- major depressive disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A5D8V6-F1 | alphafold | PREDICTED | 67.62 | — |
Amino-acid sequence (355 residues)
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA ERNLEFQGPL EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL LDLLQVEGMK IEEESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPLAM PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQL GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP AWPGY
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