Proteasome subunit beta type-11 (PSMB11)

About Proteasome subunit beta type-11

Proteasome subunit beta type-11 (PSMB11) is a protein from Homo sapiens identified by UniProt accession A5LHX3, 300 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Proteasome subunit beta type-11
UniProt accession	A5LHX3
Gene	PSMB11
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
glioblastoma multiforme · score 0.37
breast adenocarcinoma · score 0.30
endometrial cancer · score 0.29
lung adenocarcinoma · score 0.28
squamous cell lung carcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
clear cell renal carcinoma · score 0.27
gastric adenocarcinoma · score 0.27
Red cell distribution width · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A5LHX3-F1	alphafold	PREDICTED	80.42	—

Amino-acid sequence (300 residues)

MALQDVCKWQ SPDTQGPSPH LPRAGGWAVP RGCDPQTFLQ IHGPRLAHGT TTLAFRFRHG VIAAADTRSS CGSYVACPAS CKVIPVHQHL LGTTSGTSAD CATWYRVLQR ELRLRELREG QLPSVASAAK LLSAMMSQYR GLDLCVATAL CGWDRSGPEL FYVYSDGTRL QGDIFSVGSG SPYAYGVLDR GYRYDMSTQE AYALARCAVA HATHRDAYSG GSVDLFHVRE SGWEHVSRSD ACVLYVELQK LLEPEPEEDA SHAHPEPATA HRAAEDRELS VGPGEVTPGD SRMPAGTETV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards