PH and SEC7 domain-containing protein 1 (PSD)

About PH and SEC7 domain-containing protein 1

PH and SEC7 domain-containing protein 1 (PSD) is a protein from Homo sapiens identified by UniProt accession A5PKW4, 1024 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	PH and SEC7 domain-containing protein 1
UniProt accession	A5PKW4
Gene	PSD
Organism	Homo sapiens
Length	1024 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
mean corpuscular volume · score 0.24
self reported educational attainment · score 0.15
creatinine measurement · score 0.10
smoking status measurement · score 0.09
erythrocyte count · score 0.07
drug use measurement · score 0.05
triglyceride measurement · score 0.04
sex hormone-binding globulin measurement · score 0.04
neuronal ceroid lipofuscinosis 1 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A5PKW4-F1	alphafold	PREDICTED	55.47	—

Amino-acid sequence (1024 residues)

MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV AGPGPRGREL GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV VIFRFVEKAS VRPLNGLPAP GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR LEASTSDPLP ARGGSALPGS RNLVHGPPAP PQVGADGLYS SLPNGLGGPP ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDPP SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE DEDDDEAGGE EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD SFSCVFEAIL ESHRAKGTSY TSLASLEALA SPGPTQSPFF TFELPPQPPA PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RGEEEEAEAR AKLAPGREPP SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRISGGSG SGSSPFLDLT PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS RYSTYAALLR VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP SSQPRAQRHS SEPRPGAGSG RRKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards