Developmental pluripotency-associated 5 protein…

About Developmental pluripotency-associated 5 protein

Developmental pluripotency-associated 5 protein (DPPA5) is a protein from Homo sapiens identified by UniProt accession A6NC42, 116 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Developmental pluripotency-associated 5 protein
UniProt accession	A6NC42
Gene	DPPA5
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

Aganglionic megacolon · score 0.11
Hirschsprung disease · score 0.11
Abnormal central motor function · score 0.09
Down syndrome · score 0.04
embryonal carcinoma · score 0.01
neoplasm · score 0.00
neuropathy · score 0.00
Hyperlipidemia · score 0.00
hepatocellular carcinoma · score 0.00
proximal spinal muscular atrophy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NC42-F1	alphafold	PREDICTED	88.41	—

Amino-acid sequence (116 residues)

MGTLPARRHI PPWVKVPEDL KDPEVFQVQT RLLKAIFGPD GSRIPYIEQV SKAMLELKAL ESSDLTEVVV YGSYLYKLRT KWMLQSMAEW HRQRQERGML KLAEAMNALE LGPWMK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Developmental pluripotency-associated 5 protein (DPPA5)