Kelch-like protein 33 (KLHL33)

About Kelch-like protein 33

Kelch-like protein 33 (KLHL33) is a protein from Homo sapiens identified by UniProt accession A6NCF5, 533 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Kelch-like protein 33
UniProt accession	A6NCF5
Gene	KLHL33
Organism	Homo sapiens
Length	533 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

Takayasu arteritis · score 0.20
Chronic pain · score 0.06
hypertrophic cardiomyopathy · score 0.01
leprosy · score 0.01
nonpapillary renal cell carcinoma · score 0.01
renal cell carcinoma · score 0.00
Sepsis · score 0.00
papillary thyroid carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NCF5-F1	alphafold	PREDICTED	90.74	—

Amino-acid sequence (533 residues)

MLLSGMRESQ GTEVSLRTIS TQDLRLLVSF AYSGVVRARW PGLLRAAQAA LQYQSSSCLD LCQKGLARGL SPARCLALFP MAEAPGLERL WSKARHYLLT HLPAVALCPA FPSLPAACLA ELLDSDELHV QEEFEAFVAA RCWLAANPET QESEAKALLR CVRFGRMSTR ELRRVRAAGL LPPLTPDLLH QLMVEADVPG QERRREPDRA LVVIGGDGLR PDMALRQPSR AVWWARAFRC GVGLVRTVEW GQLPALPAPG RFRHGAASLA GSELYVCGGQ DFYSHSNTLA STLRWEPSQE DWEEMAPLSQ ARSLFSLVAL DGKLYALGGR HNDVALDSVE TYNPELNVWR PAPALPAPCF AHAAAILEGQ LYVSGGCGGT GQYLASLMHY DPKLEKPGTF LSPMGVPRAG HVMAALGGRL YVAGGLGETE DLLSFEAYEL RTDSWTHLAP LPSPHVGAAS AVLQGELLVL GGYSHRTYAL SHLIHAYCPG LGRWLCLGTL PRPRAEMPAC ILTLPAVQHI ALVPTPHQTK PAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards