Homeobox protein Nkx-2.6 (NKX2-6)

About Homeobox protein Nkx-2.6

Homeobox protein Nkx-2.6 (NKX2-6) is a protein from Homo sapiens identified by UniProt accession A6NCS4, 301 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Homeobox protein Nkx-2.6
UniProt accession	A6NCS4
Gene	NKX2-6
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

conotruncal heart malformations · score 0.53
neurodegenerative disease · score 0.47
BMI-adjusted waist-hip ratio · score 0.40
persistent truncus arteriosus · score 0.33
waist-hip ratio · score 0.32
BMI-adjusted waist circumference · score 0.30
physical activity measurement · score 0.26
sex interaction measurement · score 0.25
smoking behavior · score 0.23
cerebral palsy · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NCS4-F1	alphafold	PREDICTED	62.44	—

Amino-acid sequence (301 residues)

MLLSPVTSTP FSVKDILRLE RERSCPAASP HPRVRKSPEN FQYLRMDAEP RGSEVHNAGG GGGDRKLDGS EPPGGPCEAV LEMDAERMGE PQPGLNAASP LGGGTRVPER GVGNSGDSVR GGRSEQPKAR QRRKPRVLFS QAQVLALERR FKQQRYLSAP EREHLASALQ LTSTQVKIWF QNRRYKCKRQ RQDKSLELAG HPLTPRRVAV PVLVRDGKPC LGPGPGAPAF PSPYSAAVSP YSCYGGYSGA PYGAGYGTCY AGAPSGPAPH TPLASAGFGH GGQNATPQGH LAATLQGVRA W

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards