Glycerol-3-phosphate phosphatase (PGP)

About Glycerol-3-phosphate phosphatase

Glycerol-3-phosphate phosphatase (PGP) is a protein from Homo sapiens identified by UniProt accession A6NDG6, 321 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Glycerol-3-phosphate phosphatase
UniProt accession	A6NDG6
Gene	PGP
Organism	Homo sapiens
Length	321 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
lysosomal storage disease · score 0.35
body height · score 0.28
lean body mass · score 0.26
serum gamma-glutamyl transferase measurement · score 0.25
body weight · score 0.21
fat body mass · score 0.21
appendicular lean mass · score 0.18
hip circumference · score 0.17
base metabolic rate measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NDG6-F1	alphafold	PREDICTED	93.52	—

Amino-acid sequence (321 residues)

MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW RGETAVPGAP EALRALRARG KRLGFITNNS SKTRAAYAEK LRRLGFGGPA GPGASLEVFG TAYCTALYLR QRLAGAPAPK AYVLGSPALA AELEAVGVAS VGVGPEPLQG EGPGDWLHAP LEPDVRAVVV GFDPHFSYMK LTKALRYLQQ PGCLLVGTNM DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI NPERTVMVGD RLDTDILLGA TCGLKTILTL TGVSTLGDVK NNQESDCVSK KKMVPDFYVD SIADLLPALQ G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards