Metalloprotease TIKI2 (TRABD2B)

About Metalloprotease TIKI2

Metalloprotease TIKI2 (TRABD2B) is a protein from Homo sapiens identified by UniProt accession A6NFA1, 517 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Metalloprotease TIKI2
UniProt accession	A6NFA1
Gene	TRABD2B
Organism	Homo sapiens
Length	517 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.42
balding measurement · score 0.36
urate measurement · score 0.29
PHF-tau measurement · score 0.29
peak expiratory flow · score 0.24
hemoglobin measurement · score 0.18
systolic blood pressure · score 0.11
diastolic blood pressure · score 0.11
renal cell carcinoma · score 0.07
Abnormality of refraction · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NFA1-F1	alphafold	PREDICTED	68.84	—

Amino-acid sequence (517 residues)

MHAALAGPLL AALLATARAR PQPPDGGQCR PPGSQRDLNS FLWTIRRDPP AYLFGTIHVP YTRVWDFIPD NSKAAFQAST RVYFELDLTD PYTISALASC QLLPHGENLQ DVLPHELYWR LKRHLDYVKL MMPSWMTPAQ RGKGLYADYL FNAIAGNWER KRPVWVMLMV NSLTERDVRF RGVPVLDLYL AQQAEKMKKT TGAVEQVEEQ CHPLNNGLNF SQVLFALNQT LLQQESVRAG SLQASYTTED LIKHYNCGDL SAVIFNHDTS QLPNFINTTL PPHEQVTAQE IDSYFRQELI YKRNERMGKR VMALLRENED KICFFAFGAG HFLGNNTVID ILRQAGLEVD HTPAGQAIHS PAPQSPAPSP EGTSTSPAPV TPAAAVPEAP SVTPTAPPED EDPALSPHLL LPDSLSQLEE FGRQRKWHKR QSTHQRPRQF NDLWVRIEDS TTASPPPLPL QPTHSSGTAK PPFQLSDQLQ QQDPPGPASS SAPTLGLLPA IATTIAVCFL LHSLGPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards