About Transmembrane protein 235
Transmembrane protein 235 (TMEM235) is a protein
from Homo sapiens identified by UniProt accession
A6NFC5, 223 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Transmembrane protein 235 |
|---|
| UniProt accession | A6NFC5 |
|---|
| Gene | TMEM235 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 223 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- reticulocyte count · score 0.30
- eosinophil count · score 0.30
- leukocyte count · score 0.27
- rheumatoid arthritis · score 0.27
- reticulocyte measurement · score 0.26
- serum metabolite measurement · score 0.26
- myeloid white cell count · score 0.26
- lymphocyte count · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NFC5-F1 | alphafold | PREDICTED | 80.88 | — |
Amino-acid sequence (223 residues)
MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR ICEGQNGCIP LVDPFASESL DVSTSVQHLI LLHRAVIVVL PLSLVLLVCG WICGLLSSLA QSVSLLLFTG CYFLLGSVLT LAGVSIYISY SHLAFAETVQ QYGPQHMQGV RVSFGWSMAL AWGSCALEAF SGTLLLSAAW TLSLSPPICG HLSPQQVGGR GGD
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