TRPM8 channel-associated factor 2 (TCAF2)

About TRPM8 channel-associated factor 2

TRPM8 channel-associated factor 2 (TCAF2) is a protein from Homo sapiens identified by UniProt accession A6NFQ2, 919 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	TRPM8 channel-associated factor 2
UniProt accession	A6NFQ2
Gene	TCAF2
Organism	Homo sapiens
Length	919 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

neoplasm · score 0.09
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
primary familial polycythemia due to EPO receptor mutation · score 0.05
hemoglobin D disease · score 0.05
hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
dominant beta-thalassemia · score 0.05
Congenital dyserythropoietic anemia type I · score 0.05
hemoglobin H disease · score 0.04
hemoglobin E disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NFQ2-F1	alphafold	PREDICTED	92.62	—

Amino-acid sequence (919 residues)

MATIAAAAFE ALMDGVTCWD VPRGPIPSEL LLIGEAAFPV MVNDKGQVLI AASSYGRGRL VVVSHEGYLS HTGLAPFLLN AVSWLCPCPG APVGVHPSLA PLVNILQDAG LEAQVKPEPG EPLGVYCINA YNDTLTATLI QFVKHGGGLL IGGQAWYWAS QHGPDKVLSR FPGNKVTSVA GVYFTDTYGD RDRFKVSKKV PKIPLHVRYG EDVRQDQQQL LEGISELDIR TGGVPSQLLV HGALAFPLGL DASLNCFLAA AHYGRGRVVL AAHECLLCAP KMGPFLLNAV RWLARGQTGK VGVNTNLKDL CPLLSEHGLQ CSLEPHLNSD LCVYCCKAYS DKEAKQLQEF VAEGGGLLIG GQAWWWASQN PGHCPLAGFP GNIILNCFGL SILPQTLKAG CFPVPTPEMR SYHFRKALSQ FQAILNHENG NLEKSCLAKL RVDGAAFLQI PAEGVPAYIS LHRLLRKMLR GSGLPAVSRE NPVASDSYEA AVLSLATGLA HSGTDCSQLA QGLGTWTCSS SLYPSKHPIT VEINGINPGN NDCWVSTGLY LLEGQNAEVS LSEAAASAGL RVQIGCHTDD LTKARKLSRA PVVTHQCWMD RTERSVSCLW GGLLYVIVPK GSQLGPVPVT IRGAVPAPYY KLGKTSLEEW KRQMQENLAP WGELATDNII LTVPTTNLQA LKDPEPVLRL WDEMMQAVAR LAAEPFPFRR PERIVADVQI SAGWMHSGYP IMCHLESVKE IINEMDMRSR GVWGPIHELG HNQQRHGWEF PPHTTEATCN LWSVYVHETV LGIPRAQAHE ALSPPERERR IKAHLGKGAP LCDWNVWTAL ETYLQLQEAF GWEPFTQLFA EYQTLSHLPK DNTGRMNLWV KKFSEKVKKN LVPFFEAWGW PIQKEVADSL ASLPEWQENP MQVYLRARK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards