TLC domain-containing protein 2 (TLCD2)

About TLC domain-containing protein 2

TLC domain-containing protein 2 (TLCD2) is a protein from Homo sapiens identified by UniProt accession A6NGC4, 264 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	TLC domain-containing protein 2
UniProt accession	A6NGC4
Gene	TLCD2
Organism	Homo sapiens
Length	264 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

waist-hip ratio · score 0.22
neurodegenerative disease · score 0.19
serum albumin measurement · score 0.17
BMI-adjusted waist-hip ratio · score 0.14
serum alanine aminotransferase measurement · score 0.12
C-reactive protein measurement · score 0.09
alkaline phosphatase measurement · score 0.09
body height · score 0.05
triglyceride measurement · score 0.05
sex hormone-binding globulin measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NGC4-F1	alphafold	PREDICTED	86.42	—

Amino-acid sequence (264 residues)

MAPTGLLVAG ASFLAFRGLH WGLRRLPTPE SAARDRWQWW NLCVSLAHSL LSGTGALLGL SLYPQMAADP IHGHPRWALV LVAVSVGYFL ADGADLLWNQ TLGKTWDLLC HHLVVVSCLS TAVLSGHYVG FSMVSLLLEL NSACLHLRKL LLLSRQAPSL AFSVTSWASL ATLALFRLVP LGWMSLWLFR QHHQVPLALV TLGGIGLVTV GIMSIILGIR ILVNDVLQSR PHPPSPGHEK TRGTRTRRDN GPVTSNSSTL SLKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards