About Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (URAD) is a protein
from Homo sapiens identified by UniProt accession
A6NGE7, 173 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase |
|---|
| UniProt accession | A6NGE7 |
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| Gene | URAD |
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| Organism | Homo sapiens |
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| Length | 173 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- peptic ulcer disease · score 0.29
- hypothyroidism · score 0.21
- Hashimoto's thyroiditis · score 0.20
- monocyte count · score 0.16
- monocyte percentage of leukocytes · score 0.14
- neutrophil count · score 0.14
- granulocyte percentage of myeloid white cells · score 0.14
- lymphocyte percentage of leukocytes · score 0.13
- leukocyte count · score 0.13
- mean corpuscular volume · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NGE7-F1 | alphafold | PREDICTED | 95.33 | — |
Amino-acid sequence (173 residues)
MDIEKVNSMD LGEFVDVFGN ATERCPLIAA AVWSQRPFSD LEDLEKHFFA FIDALAQSGQ EGILRCHPDL AGSELQRGTL TAESQREQSG AGLRSLGADE RLRLAELNAQ YRARFGFPFV LAARFSDRTA VPRELARRLL CPSAQELRTA LGEVKKIGSL RLADLLRADP AKL
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