Coiled-coil domain-containing protein 160 (CCDC160)

About Coiled-coil domain-containing protein 160

Coiled-coil domain-containing protein 160 (CCDC160) is a protein from Homo sapiens identified by UniProt accession A6NGH7, 325 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 160
UniProt accession	A6NGH7
Gene	CCDC160
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.13
genetic disorder · score 0.12
isolated spina bifida · score 0.04
spina bifida-hypospadias syndrome · score 0.04
anencephaly 1 · score 0.03
dysraphism-cleft lip/palate-limb reduction defects syndrome · score 0.03
tropical spastic paraparesis · score 0.03
muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 · score 0.03
insomnia measurement · score 0.02
self reported educational attainment · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NGH7-F1	alphafold	PREDICTED	72.33	—

Amino-acid sequence (325 residues)

MDARRKHWKE NMFTPFFSAQ DVLEETSEPE SSSEQTTADS SKGMEEIYNL SSRKFQEESK FKRKKYIFQL NEIEQEQNLR ENKRNISKNE TDTNSASYES SNVDVTTEES FNSTEDNSTC STDNLPALLR QDIRKKFMER MSPKLCLNLL NEELEELNMK YRKIEEEFEN AEKELLHYKK EIFTKPLNFQ ETETDASKSD YELQALRNDL SEKATNVKNL SEQLQQAKEV IHKLNLENRN LKEAVRKLKH QTEVGNVLLK EEMKSYYELE MAKIRGELSV IKNELRTEKT LQARNNRALE LLRKYYASSM VTSSSILDHF TGDFF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards