PRAME family member 25 (PRAMEF25)

About PRAME family member 25

PRAME family member 25 (PRAMEF25) is a protein from Homo sapiens identified by UniProt accession A6NGN4, 478 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	PRAME family member 25
UniProt accession	A6NGN4
Gene	PRAMEF25
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NGN4-F1	alphafold	PREDICTED	84.54	—

Amino-acid sequence (478 residues)

MKMSIRTPPR LLELAGRSVL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA WPFRRLPLRP LIKMPCLETF QAVLNGLDAL LTHGVRPRRW KLQVLDLQDV CENFWMVWSE AMARGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEHLTCLL LWVKQRKDLL HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD DCGIIDSQVN AILPALSRCF ELNTFSFCGN PISMATLENL LSHTIILKNL CLELYPAPRE SYGADGTLCW SRFTQIRAEL MKRVRDLRHP KRILFGTDYC PDCGNRSFYD LEADQYCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards