IgLON family member 5 (IGLON5)

About IgLON family member 5

IgLON family member 5 (IGLON5) is a protein from Homo sapiens identified by UniProt accession A6NGN9, 336 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.

Target properties

Protein name	IgLON family member 5
UniProt accession	A6NGN9
Gene	IGLON5
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (139)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
body mass index · score 0.30
blood protein measurement · score 0.12
myeloid cell surface antigen CD33 measurement · score 0.12
Senior-Boichis syndrome · score 0.06
tauopathy · score 0.06
hepatorenocardiac degenerative fibrosis · score 0.05
kidney disease · score 0.04
encephalitis · score 0.04
Down syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NGN9-F1	alphafold	PREDICTED	83.88	—

Amino-acid sequence (336 residues)

MPPPAPGARL RLLAAAALAG LAVISRGLLS QSLEFNSPAD NYTVCEGDNA TLSCFIDEHV TRVAWLNRSN ILYAGNDRWT SDPRVRLLIN TPEEFSILIT EVGLGDEGLY TCSFQTRHQP YTTQVYLIVH VPARIVNISS PVTVNEGGNV NLLCLAVGRP EPTVTWRQLR DGFTSEGEIL EISDIQRGQA GEYECVTHNG VNSAPDSRRV LVTVNYPPTI TDVTSARTAL GRAALLRCEA MAVPPADFQW YKDDRLLSSG TAEGLKVQTE RTRSMLLFAN VSARHYGNYT CRAANRLGAS SASMRLLRPG SLENSAPRPP GLLALLSALG WLWWRM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards