Otolin-1 (OTOL1)

About Otolin-1

Otolin-1 (OTOL1) is a protein from Homo sapiens identified by UniProt accession A6NHN0, 477 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Otolin-1
UniProt accession	A6NHN0
Gene	OTOL1
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.38
lean body mass · score 0.33
body mass index · score 0.32
fat body mass · score 0.31
body weight · score 0.28
alcohol consumption measurement · score 0.27
self reported educational attainment · score 0.27
schizophrenia · score 0.26
whole body water mass · score 0.21
waist circumference · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NHN0-F1	alphafold	PREDICTED	58.95	—

Amino-acid sequence (477 residues)

MWMFSWLCAI LIILAIAGMN TIAKTTPHTK FTKKSEEREM PKGLKPSSGP PPEEEETLFT EMAEMAEPIT KPSALDSVFG TATLSPFENF TLDPADFFLN CCDCCSPVPG QKGEPGETGQ PGPKGEAGNL GIPGPPGVVG PQGPRGYKGE KGLKGERGDQ GVPGYPGKPG AQGEPGPKGD KGNIGLGGVK GQKGSKGDTC GNCTKGEKGD QGAMGSPGLH GGPGAKGEKG EMGEKGEMGD KGCCGDSGER GGKGQKGEGG MKGEKGSKGD SGMEGKSGRN GLPGAKGDPG IKGEKGELGP PGLLGPTGPK GDIGNKGVRG PTGKKGSRGF KGSKGELARV PRSAFSAGLS KPFPPPNIPI KFEKILYNDQ GNYSPVTGKF NCSIPGTYVF SYHITVRGRP ARISLVAQNK KQFKSRETLY GQEIDQASLL VILKLSAGDQ VWLEVSKDWN GVYVSAEDDS IFTGFLLYPE ETSGISP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards