RING finger protein 227 (RNF227)

About RING finger protein 227

RING finger protein 227 (RNF227) is a protein from Homo sapiens identified by UniProt accession A6NIN4, 190 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	RING finger protein 227
UniProt accession	A6NIN4
Gene	RNF227
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.15
smoking status measurement · score 0.09
antisocial behaviour measurement · score 0.07
substance abuse · score 0.07
attention deficit hyperactivity disorder · score 0.07
macula measurement · score 0.05
reticulocyte measurement · score 0.04
reticulocyte count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NIN4-F1	alphafold	PREDICTED	69.03	—

Amino-acid sequence (190 residues)

MQLLVRVPSL PERGELDCNI CYRPFNLGCR APRRLPGTAR ARCGHTICTA CLRELAARGD GGGAAARVVR LRRVVTCPFC RAPSQLPRGG LTEMALDSDL WSRLEEKARA KCERDEAGNP AKESSDADGE AEEEGESEKG AGPRSAGWRA LRRLWDRVLG PARRWRRPLP SNVLYCAEIK DIGHLTRCTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards