About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP5) is a protein
from Homo sapiens identified by UniProt accession
A6NIR3, 686 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 |
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| UniProt accession | A6NIR3 |
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| Gene | AGAP5 |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.21
- atrial flutter · score 0.20
- diastolic blood pressure · score 0.18
- eosinophil count · score 0.14
- chronic obstructive pulmonary disease · score 0.09
- systolic blood pressure · score 0.08
- cardiac arrhythmia · score 0.08
- C-reactive protein measurement · score 0.05
- electrocardiography · score 0.05
- hypertrophic cardiomyopathy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NIR3-F1 | alphafold | PREDICTED | 62.25 | — |
Amino-acid sequence (686 residues)
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV
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