Leucine-rich repeat-containing protein 72 (LRRC72)

About Leucine-rich repeat-containing protein 72

Leucine-rich repeat-containing protein 72 (LRRC72) is a protein from Homo sapiens identified by UniProt accession A6NJI9, 287 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 72
UniProt accession	A6NJI9
Gene	LRRC72
Organism	Homo sapiens
Length	287 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.29
calcium measurement · score 0.05
protein measurement · score 0.05
neurofibrillary tangles measurement · score 0.04
BMI-adjusted hip circumference · score 0.03
serum albumin measurement · score 0.03
balding measurement · score 0.03
carpal tunnel syndrome · score 0.03
cortical surface area measurement · score 0.02
brain measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NJI9-F1	alphafold	PREDICTED	79.19	—

Amino-acid sequence (287 residues)

MSWDPNPVPR TLRCWRLRRA SETALQSSRR AVEDQLKICG HRRDADVFEL FLSKKELTEV IDLSRFKKLK YLWLHHNKLH GITFLTRNYC LTELYLNNNA IFEIEGLHYL PSLHILLLHH NELTNIDATV KELKGMLNLK ILSLYQNPLC QYNLYRLYII YHLPGVELLD RNQVTEKERR SMITIFNHKK AHIVQSIAFG GKVDASWDPK SPFKQKPAQR VPSDFAFANN VDKTVLDDPE DAVFVRSMKR SVMTLTSMNW DTVPTREERY LEEEGTETAQ MLTVTLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards