Putative aquaporin-12B (AQP12B)

About Putative aquaporin-12B

Putative aquaporin-12B (AQP12B) is a protein from Homo sapiens identified by UniProt accession A6NM10, 295 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Putative aquaporin-12B
UniProt accession	A6NM10
Gene	AQP12B
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

ulcerative colitis · score 0.07
Hyperlipoproteinemia type 1 · score 0.05
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
thrombocytopenia 4 · score 0.05
chronic pancreatitis · score 0.05
congenital amegakaryocytic thrombocytopenia 1 · score 0.04
thrombocytopenia 7 · score 0.04
thyroid hormone metabolism, abnormal, 2 · score 0.04
autosomal dominant macrothrombocytopenia · score 0.04
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NM10-F1	alphafold	PREDICTED	79.96	—

Amino-acid sequence (295 residues)

MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL LKLAAQGLGM QAACTLTRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards