Leucine-rich repeat-containing protein 30 (LRRC30)

About Leucine-rich repeat-containing protein 30

Leucine-rich repeat-containing protein 30 (LRRC30) is a protein from Homo sapiens identified by UniProt accession A6NM36, 301 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 30
UniProt accession	A6NM36
Gene	LRRC30
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

obesity · score 0.23
gut microbiome measurement · score 0.20
bone density · score 0.19
Blackfan-Diamond anemia · score 0.09
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
delta-beta-thalassemia · score 0.06
hemoglobin D disease · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A6NM36-F1	alphafold	PREDICTED	90.11	—

Amino-acid sequence (301 residues)

MGARQSRASS KDKGPKRMLF TGRRQKFSPW DDALLSGRDP RSLLKRGMHH VSFSLVTRGM TDIPDFLWGL SEVQKLNLSH NQLRVLPPEV GKLTRIVVLN LCGNRLKSLP REVSLLQCLK VLFVNMNCLT EVPAELSLCR KLEVLSLSHN CLSQLPACFA DLSRLRKLNL SNNFFAHIPM CVFSLKELIF LHVGSNRLEN IAESIQHLAS LQIFIAEGNN IHSFPRSLCL VTSLELLNLN NNDIQTLPSE LHLLCRLVRI AWNPMDKGLH ISHNPLSKPL PELVEGGLEM LFGYLKDKKH T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards