About Leucine-rich repeat-containing protein 37A
Leucine-rich repeat-containing protein 37A (LRRC37A) is a protein
from Homo sapiens identified by UniProt accession
A6NMS7, 1700 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 37A |
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| UniProt accession | A6NMS7 |
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| Gene | LRRC37A |
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| Organism | Homo sapiens |
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| Length | 1700 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- Koolen-de Vries syndrome · score 0.34
- reaction time measurement · score 0.25
- white matter microstructure measurement · score 0.22
- alcohol drinking · score 0.20
- forced expiratory volume · score 0.19
- mean corpuscular volume · score 0.18
- diet measurement · score 0.18
- neutrophil count · score 0.17
- reticulocyte count · score 0.17
- mean corpuscular hemoglobin · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NMS7-F1 | alphafold | PREDICTED | 42.02 | — |
Amino-acid sequence (1700 residues)
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT SNPLGPPESW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ ESTENLVPFL DTWDSAGEQP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL KKDPAQRWSL AEIIGITRQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP MEHELSISEQ QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQPPD LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV PLTTLKNILM MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIVEPE EPSDSSGINL SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP FSKGTPSTSS PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH ARKKYRFHKT RSHVTHRTTK VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL INSPSQGAFS SLGDLSPQEN PFLEVSALSE HFIEKNNTKH TTARNAFEEN DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN YINESTEAQS EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC LIVICCHRRS LQEDEEGFSR GIFRFLPWRG CSSRRESQDG LSSFGQPLWF KDLYKPLSAT RINNHAWKLH KKSSNEDKIL NRDPGDSEAP TEEEESEALP
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