About Interferon-induced transmembrane protein 5
Interferon-induced transmembrane protein 5 (IFITM5) is a protein
from Homo sapiens identified by UniProt accession
A6NNB3, 132 residues long.
MolForge cross-references it against 0 known binders and
290 disease associations.
Target properties
| Protein name | Interferon-induced transmembrane protein 5 |
|---|
| UniProt accession | A6NNB3 |
|---|
| Gene | IFITM5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 132 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (290)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta type 5 · score 0.77
- osteogenesis imperfecta · score 0.41
- alkaline phosphatase measurement · score 0.38
- Skeletal dysplasia · score 0.37
- postmenopausal osteoporosis · score 0.34
- genetic disorder · score 0.19
- Hypocalcemic vitamin D-resistant rickets · score 0.07
- metaphyseal dysplasia, Braun-Tinschert type · score 0.07
- sex hormone-binding globulin measurement · score 0.07
- cleidocranial dysplasia 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NNB3-F1 | alphafold | PREDICTED | 65.31 | — |
Amino-acid sequence (132 residues)
MDTAYPREDT RAPTPSKAGA HTALTLGAPH PPPRDHLIWS VFSTLYLNLC CLGFLALAYS IKARDQKVVG DLEAARRFGS KAKCYNILAA MWTLVPPLLL LGLVVTGALH LARLAKDSAA FFSTKFDDAD YD
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