About NUT family member 2B
NUT family member 2B (NUTM2B) is a protein
from Homo sapiens identified by UniProt accession
A6NNL0, 878 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | NUT family member 2B |
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| UniProt accession | A6NNL0 |
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| Gene | NUTM2B |
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| Organism | Homo sapiens |
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| Length | 878 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- endometrial stromal sarcoma · score 0.37
- clear cell sarcoma · score 0.37
- solitary fibrous tumor · score 0.37
- Uterine Carcinosarcoma · score 0.37
- angiosarcoma · score 0.37
- embryonal rhabdomyosarcoma · score 0.37
- malignant peripheral nerve sheath tumor · score 0.37
- leiomyosarcoma · score 0.37
- dedifferentiated liposarcoma · score 0.37
- synovial sarcoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NNL0-F1 | alphafold | PREDICTED | 45.34 | — |
Amino-acid sequence (878 residues)
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST FPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV PDPQQGVGME TCPPQMTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AAWPTSPPQD HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPYPGPGL RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ
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