About Solute carrier family 38 member 8
Solute carrier family 38 member 8 (SLC38A8) is a protein
from Homo sapiens identified by UniProt accession
A6NNN8, 435 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Solute carrier family 38 member 8 |
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| UniProt accession | A6NNN8 |
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| Gene | SLC38A8 |
|---|
| Organism | Homo sapiens |
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| Length | 435 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (164)
Diseases linked to this target (Open Targets).
- foveal hypoplasia - optic nerve decussation defect - anterior segment dysgenesis syndrome · score 0.80
- Foveal hypoplasia-optic nerve decussation defect-anterior segment dysgenesis syndrome · score 0.75
- foveal hypoplasia · score 0.42
- Hypoplasia of the fovea · score 0.42
- genetic disorder · score 0.41
- Leber congenital amaurosis · score 0.28
- schizophrenia · score 0.11
- Herpes Zoster · score 0.11
- retinitis pigmentosa · score 0.09
- attention deficit hyperactivity disorder · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NNN8-F1 | alphafold | PREDICTED | 83.67 | — |
Amino-acid sequence (435 residues)
MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS KAGGVVPAFL VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI GKLCEACFLL NLLMISVAFL RVIGDQLEKL CDSLLSGTPP APQPWYADQR FTLPLLSVLV ILPLSAPREI AFQKYTSILG TLAACYLALV ITVQYYLWPQ GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC SMRKRSLSHW ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL TILWVTVTLA MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI GPRVKCCLEV WGVVSVLVGT FIFGQSTAAA VWEMF
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