About Enolase 4
Enolase 4 (ENO4) is a protein
from Homo sapiens identified by UniProt accession
A6NNW6, 625 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Enolase 4 |
|---|
| UniProt accession | A6NNW6 |
|---|
| Gene | ENO4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 625 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (149)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.45
- body mass index · score 0.42
- mathematical ability · score 0.35
- cortical surface area measurement · score 0.33
- body fat percentage · score 0.32
- neuroimaging measurement · score 0.31
- body height · score 0.30
- lean body mass · score 0.30
- cortical thickness · score 0.29
- brain measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6NNW6-F1 | alphafold | PREDICTED | 84.43 | — |
Amino-acid sequence (625 residues)
MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD VYGHLANCFS KLAKPPTICK IVGKDVLDGL GLPTLQVDIF CTIQNFPKNV CSVVISTHFE VHENALPELA KAEEAERASA VSTAVQWVNS TITHELQGMA PSDQAEVDHL LRIFFASKVQ EDKGRKELEK SLEYSTVPTP LPPVPPPPPP PPPTKKKGQK PGRKDTITEK PIAPAEPVEP VLSGSMAIGA VSLAVAKACA MLLNKPLYLN IALLKHNQEQ PTTLSMPLLM VSLVSCGKSS SGKLNLMKEV ICIPHPELTT KQGVEMLMEM QKHINKIIEM PSPPKAETKK GHDGSKRGQQ QITGKMSHLG CLTINCDSIE QPLLLIQEIC ANLGLELGTN LHLAINCAGH ELMDYNKGKY EVIMGTYKNA AEMVDLYVDL INKYPSIIAL IDPFRKEDSE QWDSIYHALG SRCYIIAGTA SKSISKLLEQ GNISIPKSNG LIIKHTNQTT MSDLVEITNL IDSKKHITVF GSTEGESSDD SLVDLAVGLG VRFIKLGGLS RGERVTKYNR LLTIEEELVQ NGTLGFKEEH TFFYFNEEAE KAAEALEAAA AREPLVPTFP TQGVEESAET GASSG
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