About Leucine-rich repeat and IQ domain-containing protein 3
Leucine-rich repeat and IQ domain-containing protein 3 (LRRIQ3) is a protein
from Homo sapiens identified by UniProt accession
A6PVS8, 624 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Leucine-rich repeat and IQ domain-containing protein 3 |
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| UniProt accession | A6PVS8 |
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| Gene | LRRIQ3 |
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| Organism | Homo sapiens |
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| Length | 624 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.43
- health study participation · score 0.32
- DNA methylation · score 0.31
- mathematical ability · score 0.26
- neurodegenerative disease · score 0.25
- lymphocyte count · score 0.20
- cognitive function measurement · score 0.19
- body fat percentage · score 0.05
- fat body mass · score 0.03
- lean body mass · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A6PVS8-F1 | alphafold | PREDICTED | 70.14 | — |
Amino-acid sequence (624 residues)
MFHGTVTEEL TSHEEWSHYN ENIREGQKDF VFVKFNGLHL KSMENLQSCI SLRVCIFSNN FITDIHPLQS CIKLIKLDLH GNQIKSLPNT KFWNGLKNLK LLYLHDNGFA KLKNICVLSA CPTLIALTMF DCPVSLKKGY RHVLVNSIWP LKALDHHVIS DEEIIQNWHL PERFKACNHR LFFNFCPALR KGTTYEEEIN NIKHITSKIN AILAHNSPVL IVQRWIRGFL VRKNLSPVFF HKKKQQEKII RGYEAKWIYI TKGYEDKLLK DLFFKPETNI KGKLAYWKHN IYYPVDLKNS SEHRKHVSSI LCELKPKDLG MKSKTSRHLI QKGQESEDEI VDEKLDTSFR ISVFKLPIYT SGSLKNNAVL REKKQHFFPA YPQPIYTTHP KPIIKKDIRL ERSMKEFFAP QRAGMKLRTF SDIDKYYTEQ KKQEYHKEKV RVVAMAQVAR ERVRVAVNEH LNQKKYATQK LIEENKETIQ NSLRQVWQNR FNYLEKARER KALFLKEKSQ KASERLLVQN LNNERTLLTR GLLKIDRLEK NEAVLKEKSL IVKQKLKAEK YRKNLLKEMK KVRSQEIYKR HCEEKFVMDM IAFEKACERL QDAKTKVAIV KTNLDFKVPN GLIK
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