About Serine/arginine repetitive matrix protein 4
Serine/arginine repetitive matrix protein 4 (SRRM4) is a protein
from Homo sapiens identified by UniProt accession
A7MD48, 611 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Serine/arginine repetitive matrix protein 4 |
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| UniProt accession | A7MD48 |
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| Gene | SRRM4 |
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| Organism | Homo sapiens |
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| Length | 611 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- t-tau measurement · score 0.35
- neurodegenerative disease · score 0.35
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.28
- diabetes mellitus · score 0.15
- type 1 diabetes mellitus · score 0.15
- small cell lung carcinoma · score 0.09
- neoplasm · score 0.09
- cancer · score 0.08
- essential tremor · score 0.07
- Young adult-onset Parkinsonism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A7MD48-F1 | alphafold | PREDICTED | 47.88 | — |
Amino-acid sequence (611 residues)
MASVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARK PLPRTEPQNN PVVPAQDGPS EKLGQHLATE PLGTNSWERD KTCRELGATR GHSASHDKDL TPPPSSRGKK KKKKSTRKKR RRSSSYSPSP VKKKKKKSSK KHKRRRSFSK KRRHSSSSPK SKRRDEKRHK KQSRSRPRKS HRHRHHRCPS RSQSSESRPS SCESRHRGRS PEEGQKSRRR HSRRCSKTLC KDSPEAQSSR PPSQPLQMLG YLSARGVITG SGSAADLFTK TASPLTTSRG RSQEYDSGND TSSPPSTQTS SARSRGQEKG SPSGGLSKSR ELNSGNTSDS GNSFTTSSPQ NKGAMLENLS PTSRGRESRG FQSPCLECAE VKKSSLVPST ARSSPMKGCS RSSSYASTRS SSHSSRSPNP RASPRYTQSR STSSEKRSYS RSPSYSSKSG KRSPPSRSSR SRRSPSYSRY SPSRERDPKY SEKDSQQRER ERARRRRRSY SPMRKRRRDS PSHLEARRIT SARKRPIPYY RPSPSSSGSL SSTSSWYSSS SSRSASRSYS RSRSRSRSRR RSRTRTSSSS SSRSPSPGSR SRSRSRSRSR SRSRSQSRSY SSADSYSSTR R
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