About Zinc finger protein 839
Zinc finger protein 839 (ZNF839) is a protein
from Homo sapiens identified by UniProt accession
A8K0R7, 811 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Zinc finger protein 839 |
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| UniProt accession | A8K0R7 |
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| Gene | ZNF839 |
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| Organism | Homo sapiens |
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| Length | 811 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- platelet count · score 0.30
- DNA methylation · score 0.29
- mean corpuscular volume · score 0.29
- body mass index · score 0.21
- urate measurement · score 0.18
- glomerular filtration rate · score 0.17
- diet measurement · score 0.13
- hemoglobin measurement · score 0.13
- mean corpuscular hemoglobin concentration · score 0.09
- inosine-5'-monophosphate dehydrogenase 2 measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8K0R7-F1 | alphafold | PREDICTED | 49.51 | — |
Amino-acid sequence (811 residues)
MLLPTTIQPQ TARKSQLPRG NSCLVGLHIA SPQLLRVQPL VRTEPQSCFL SDLCQPPAQG FVQRPLPALQ VVPAKRVPAP KAPDEQGSML TPLSASDPLA VTSLSSSSAH PFISNLHTRH TEKLKKSLKV KTRSGRVSRP PKYKAKDYKF IKTEDLADGH LSDSDDYSEL CVEEDEDQRE RHALFDLSSC SLRPKSFKCQ TCEKSYIGKG GLARHFKLNP GHGQLDPEMV LSEKASGSTL RGCTEERTLS LTSLGLSMPA DPCEGGARSC LVTESARGGL QNGQSVDVEE TLPSEPENGA LLRSERYQGP RRRACSETLA ESRTAVLQQR RAAQLPGGPA AAGEQRASPS KARLKEFLQQ CDREDLVELA LPQLAQVVTV YEFLLMKVEK DHLAKPFFPA IYKEFEELHK MVKKMCQDYL SSSGLCSQET LEINNDKVAE SLGITEFLRK KEIHPDNLGP KHLSRDMDGE QLEGASSEKR EREAAEEGLA SVKRPRREAL SNDTTESLAA NSRGREKPRP LHALAAGFSP PVNVTVSPRS EESHTTTVSG GNGSVFQAGP QLQALANLEA RRGSIGAALS SRDVSGLPVY AQSGEPRRLT QAQVAAFPGE NALEHSSDQD TWDSLRSPGF CSPLSSGGGA ESLPPGGPGH AEAGHLGKVC DFHLNHQQPS PTSVLPTEVA APPLEKILSV DSVAVDCAYR TVPKPGPQPG PHGSLLTEGC LRSLSGDLNR FPCGMEVHSG QRELESVVAV GEAMAFEISN GSHELLSQGQ KQIFIQTSDG LILSPPGTIV SQEEDIVTVT DAEGRACGWA R
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