About Protein phosphatase 2C-like domain-containing protein 1
Protein phosphatase 2C-like domain-containing protein 1 (PP2D1) is a protein
from Homo sapiens identified by UniProt accession
A8MPX8, 630 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Protein phosphatase 2C-like domain-containing protein 1 |
|---|
| UniProt accession | A8MPX8 |
|---|
| Gene | PP2D1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 630 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- testosterone measurement · score 0.26
- total blood protein measurement · score 0.24
- psychiatric disorder · score 0.22
- heel bone mineral density · score 0.17
- protein measurement · score 0.10
- lean body mass · score 0.08
- fat body mass · score 0.07
- body mass index · score 0.07
- mean corpuscular volume · score 0.04
- body fat percentage · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MPX8-F1 | alphafold | PREDICTED | 71.53 | — |
Amino-acid sequence (630 residues)
MSTNNALRVF WKSREWNMKT STFDSDEDIL LLPKRKRFRK KKSRPVRHTK RHEEEQVYEQ GTTLPCSICK HEIDLTGIFL HKKQHVALAT LGFQWMGRKK PQPSVIAVQR QFMISKLLSS FMFTEKTLQS INNAFELLWK KQIPAYYKIF DNIDRSVIYS QKICHLLIKG VGICEDRNST WKADMNDKFT VVSNFGNKPN VCFFGLFDGH HGASAAELTS MELPVLLLHQ LSKFDPSYQM TTDEQQIINS FYTVFREEYA AIEDLFSAIN KTEAVRCEYE DTHKAFAKAF WRMDRLLGLG RKEVSRVQWS GCSAVTCILE GKPKSPYAHK NWKRKNTHDG LAESSPSQEM PKIISGILHV ANTGNVQAVL CRNGKGFCLT KEHTTRNTNE RRRILQNGAV ISSNEPYGLV EGQVKTTRGL GFHGNLKLKK SIIPAPQTIS VPIDDLCQFL IVATNGLWEV LDKEEVTALA MTTFHMYKET YCPIIPNKSP SKGPLLFSTS EPNLTKSQSN IHVLFQYKSV SEVRVSTTNS KENLSDSNYS KYCIYNPENV ETFPAETTHR KPCSEKVTDR PTSVNDVATN EKESDTKSFY EGAAEYVSHE LVNAALLAGS RDNITVMVIF LNGSEYQLLT
Explore Protein phosphatase 2C-like domain-containing protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets