About Synaptonemal complex central element protein 1-like
Synaptonemal complex central element protein 1-like (SYCE1L) is a protein
from Homo sapiens identified by UniProt accession
A8MT33, 242 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Synaptonemal complex central element protein 1-like |
|---|
| UniProt accession | A8MT33 |
|---|
| Gene | SYCE1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.35
- insomnia measurement · score 0.32
- aspartate aminotransferase measurement · score 0.31
- body mass index · score 0.27
- neutrophil count · score 0.22
- leukocyte count · score 0.22
- myeloid white cell count · score 0.22
- risky sexual behaviour measurement · score 0.20
- wellbeing measurement · score 0.20
- depressive symptom measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MT33-F1 | alphafold | PREDICTED | 78.97 | — |
Amino-acid sequence (242 residues)
MAGKLKPLNV EAPEATEEAE GQAKSLKTED LLAMVIKLQK EGSLEPQIED LISRINDLQQ AKKKSSEELR ETHSLWEALH RELDSLNGEK VHLEEVLGKK QEALRILQMH CQEKESEAQR LDVRGQLEDL MGQHKDLWEF HMLEQRLARE IRALERSKEQ LLSERRLVRA KLREVERRLH SPPEVEGAMA VNDGLKAELE IFGEQVRSAP EVGAGEGEAG PELPRARDEE DPEPPVAAPD AL
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