About Guanine nucleotide-binding protein G(t) subunit alpha-3
Guanine nucleotide-binding protein G(t) subunit alpha-3 (GNAT3) is a protein
from Homo sapiens identified by UniProt accession
A8MTJ3, 354 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein G(t) subunit alpha-3 |
|---|
| UniProt accession | A8MTJ3 |
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| Gene | GNAT3 |
|---|
| Organism | Homo sapiens |
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| Length | 354 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.43
- C-reactive protein measurement · score 0.32
- platelet component distribution width · score 0.32
- endometrial cancer · score 0.27
- myeloid white cell count · score 0.27
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.25
- esophageal cancer · score 0.24
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MTJ3-F1 | alphafold | PREDICTED | 93.87 | — |
Amino-acid sequence (354 residues)
MGSGISSESK ESAKRSKELE KKLQEDAERD ARTVKLLLLG AGESGKSTIV KQMKIIHKNG YSEQECMEFK AVIYSNTLQS ILAIVKAMTT LGIDYVNPRS AEDQRQLYAM ANTLEDGGMT PQLAEVIKRL WRDPGIQACF ERASEYQLND SAAYYLNDLD RITASGYVPN EQDVLHSRVK TTGIIETQFS FKDLHFRMFD VGGQRSERKK WIHCFEGVTC IIFCAALSAY DMVLVEDEEV NRMHESLHLF NSICNHKYFS TTSIVLFLNK KDIFQEKVTK VHLSICFPEY TGPNTFEDAG NYIKNQFLDL NLKKEDKEIY SHMTCATDTQ NVKFVFDAVT DIIIKENLKD CGLF
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