About Homeobox protein notochord
Homeobox protein notochord (NOTO) is a protein
from Homo sapiens identified by UniProt accession
A8MTQ0, 251 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Homeobox protein notochord |
|---|
| UniProt accession | A8MTQ0 |
|---|
| Gene | NOTO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 251 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.12
- intelligence · score 0.06
- diastolic blood pressure · score 0.05
- mean arterial pressure · score 0.05
- breast carcinoma · score 0.04
- cognitive function measurement · score 0.02
- nail-patella syndrome · score 0.01
- Osteoporosis · score 0.01
- age · score 0.00
- aging · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MTQ0-F1 | alphafold | PREDICTED | 67.42 | — |
Amino-acid sequence (251 residues)
MPSPRPRGSP PPAPSGSRVR PPRSGRSPAP RSPTGPNTPR APGRFESPFS VEAILARPDP CAPAASQPSG SACVHPAFWT AASLCATGGL PWACPTSWLP AYLSVGFYPV PGPRVAPVCG LLGFGVTGLE LAHCSGLWAF PDWAPTEDLQ DTERQQKRVR TMFNLEQLEE LEKVFAKQHN LVGKKRAQLA ARLKLTENQV RVWFQNRRVK YQKQQKLRAA VTSAEAASLD EPSSSSIASI QSDDAESGVD G
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