About Protein FAM171A2
Protein FAM171A2 (FAM171A2) is a protein
from Homo sapiens identified by UniProt accession
A8MVW0, 826 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Protein FAM171A2 |
|---|
| UniProt accession | A8MVW0 |
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| Gene | FAM171A2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 826 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- progranulin measurement · score 0.25
- mean platelet volume · score 0.20
- platelet-to-lymphocyte ratio · score 0.18
- blood protein measurement · score 0.17
- platelet count · score 0.16
- platelet component distribution width · score 0.16
- Alzheimer disease · score 0.09
- platelet crit · score 0.09
- late-onset Alzheimers disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-A8MVW0-F1 | alphafold | PREDICTED | 58.83 | — |
Amino-acid sequence (826 residues)
MPPASGPSVL ARLLPLLGLL LGSASRAPGK SPPEPPSPQE ILIKVQVYVS GELVPLARAS VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV SLYLLPERPA TLILYEDLVH ILLGSPGARS QPLVQFQRRA ARLPVSSTYS QLWASLTPAS TQQEMRAFPA FLGTEASSSG NGSWLELMPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE TRALTVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS DGNKRDQATS MSQLHLICGG PLEPAPSGDP EAPPPGPLHS AFSSSRDLAS SRDDFFRTKP RSASRPAAEP SGARGGESAG LKGARSAEGP GGLEPGLEEH RRGPSGAAAF LHEPPSPPPP FDHYLGHKGA AEGKTPDFLL SQSVDQLARP PSLGQAGQLI FCGSIDHLKD NVYRNVMPTL VIPAHYVRLG GEAGAAGVGD EPAPPEGTAP GPARAFPQPD PQRPQMPGHS GPGGEGGGGG GEGWGAGRAA PVSGSVTIPV LFNESTMAQL NGELQALTEK KLLELGVKPH PRAWFVSLDG RSNSQVRHSY IDLQAGGGAR STDASLDSGV DVHEARPARR RPAREERERA PPAAPPPPPA PPRLALSEDT EPSSSESRTG LCSPEDNSLT PLLDEVAAPE GRAATVPRGR GRSRGDSSRS SASELRRDSL TSPEDELGAE VGDEAGDKKS PWQRREERPL MVFNVK
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