HEPACAM family member 2 (HEPACAM2)

About HEPACAM family member 2

HEPACAM family member 2 (HEPACAM2) is a protein from Homo sapiens identified by UniProt accession A8MVW5, 462 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	HEPACAM family member 2
UniProt accession	A8MVW5
Gene	HEPACAM2
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
prostate cancer · score 0.11
diabetic retinopathy · score 0.09
Barrett's esophagus · score 0.08
esophageal adenocarcinoma · score 0.05
age at menopause · score 0.05
clear cell renal carcinoma · score 0.04
breast carcinoma · score 0.04
metabolite measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A8MVW5-F1	alphafold	PREDICTED	78.64	—

Amino-acid sequence (462 residues)

MGQDAFMEPF GDTLGVFQCK IYLLLFGACS GLKVTVPSHT VHGVRGQALY LPVHYGFHTP ASDIQIIWLF ERPHTMPKYL LGSVNKSVVP DLEYQHKFTM MPPNASLLIN PLQFPDEGNY IVKVNIQGNG TLSASQKIQV TVDDPVTKPV VQIHPPSGAV EYVGNMTLTC HVEGGTRLAY QWLKNGRPVH TSSTYSFSPQ NNTLHIAPVT KEDIGNYSCL VRNPVSEMES DIIMPIIYYG PYGLQVNSDK GLKVGEVFTV DLGEAILFDC SADSHPPNTY SWIRRTDNTT YIIKHGPRLE VASEKVAQKT MDYVCCAYNN ITGRQDETHF TVIITSVGLE KLAQKGKSLS PLASITGISL FLIISMCLLF LWKKYQPYKV IKQKLEGRPE TEYRKAQTFS GHEDALDDFG IYEFVAFPDV SGVSRIPSRS VPASDCVSGQ DLHSTVYEVI QHIPAQQQDH PE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards